CHADL Gene Summary [Human]
Enables collagen binding activity and collagen fibril binding activity. Involved in negative regulation of collagen fibril organization. Located in collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CHADL |
| Official Name | chondroadherin like [Source:HGNC Symbol;Acc:HGNC:25165] |
| Ensembl ID | ENSG00000100399 |
| Bio databases IDs | |
| Aliases | chondroadherin like |
| Synonyms | chondroadherin-like, D930017K21Rik, SLRR4B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CHADL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- protein phosphatase 1 regulatory subunit 42
- extracellular matrix structural constituent conferring compression resistance
- extracellular matrix binding
- Leucine rich repeat
- collagen binding
- Leucine rich repeat C-terminal domain
- Leucine rich repeat N-terminal domain
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CHADL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of chondrocyte differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- external side of plasma membrane
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- collagen binding
- extracellular matrix structural constituent conferring compression resistance