CERK Gene Summary [Human]
CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | CERK |
| Official Name | ceramide kinase [Source:HGNC Symbol;Acc:HGNC:19256] |
| Ensembl ID | ENSG00000100422 |
| Bio databases IDs | |
| Aliases | ceramide kinase |
| Synonyms | ceramide kinase, CK, D330016D08Rik, dA59H18.2, dA59H18.3, hCERK, LK4, LOC103694581, mKIAA1646 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CERK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Ceramide kinase C-terminal domain
- Diacylglycerol kinase catalytic domain
- protein binding
- magnesium ion binding
- ceramide kinase
Pathways
Biological processes and signaling networks where the CERK gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- gait disturbance
- schizophrenia
- allergic rhinitis
- infection by bacteria
role in cell
- expression in
- proliferation
- migration
- invasion by
- cell death
- number
- phagocytosis
- activation
- survival
- induction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CERK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ceramide metabolic process
- phosphorylation
- glycosphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein binding
- ceramide kinase activity