MTNR1A Gene Summary [Human]
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MTNR1A |
| Official Name | melatonin receptor 1A [Source:HGNC Symbol;Acc:HGNC:7463] |
| Ensembl ID | ENSG00000168412 |
| Bio databases IDs | |
| Aliases | melatonin receptor 1A |
| Synonyms | MEL-1A-R, melatonin receptor 1A, MelR, MR, MT1, MT1 receptor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MTNR1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- hormone binding
- Cholecystokinin A receptor, N-terminal
- melatonin receptor
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- tail domain
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the MTNR1A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- obesity
- fatigue
- COVID-19
- asthenia
- schizophrenia
- migraines
- locally advanced oral squamous cell carcinoma
- dyssomnia
- brain damage
role in cell
- expression in
- number
- abnormal morphology
- function
- recruitment in
- activation in
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Mitochondria
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MTNR1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- mating behavior
- G-protein coupled receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- circadian rhythm
Cellular Component
Where in the cell the gene product is active
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- organic cyclic compound binding
- hormone binding
- melatonin receptor activity