GZMH Gene Summary [Human]
This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | GZMH |
| Official Name | granzyme H [Source:HGNC Symbol;Acc:HGNC:4710] |
| Ensembl ID | ENSG00000100450 |
| Bio databases IDs | |
| Aliases | granzyme H, cathepsin G-like 2, protein h-CCPX |
| Synonyms | B10, Cathepsin G-like 2, CCP2, CCP-X, CGL-2, CSP-C, CTLA1, Ctla-5, CTSGL2, granzyme C, granzyme H, Grz c, Gzmc |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GZMH often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- serine endopeptidase
- peptidase
- Trypsin-like peptidase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic periodontal disease
- sporadic amyotrophic lateral sclerosis
- sepsis
role in cell
- cell death
- depolarization
- condensation
- swelling
- molecular cleavage in
- collapse
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome
- granules
- cytotoxic granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GZMH gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- apoptotic process
- killing of cells of other organism
Cellular Component
Where in the cell the gene product is active
- cytolytic granule
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase activity