Gzmc Gene Summary [Mouse]
This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate a mature protein product. This product, expressed by activated T cells, may induce apoptosis of target cells. This gene is present in a gene cluster with other members of the granzyme subfamily on chromosome 14. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | Gzmc |
| Official Name | granzyme C [Source:MGI Symbol;Acc:MGI:109256] |
| Ensembl ID | ENSMUSG00000079186 |
| Bio databases IDs | |
| Aliases | granzyme C |
| Synonyms | B10, Cathepsin G-like 2, CCP2, CCP-X, CGL-2, CSP-C, CTLA1, Ctla-5, CTSGL2, granzyme C, granzyme H, Grz c, Gzmc |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gzmc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- serine endopeptidase
- peptidase
- Trypsin-like peptidase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic periodontal disease
- sporadic amyotrophic lateral sclerosis
- sepsis
role in cell
- cell death
- depolarization
- condensation
- swelling
- molecular cleavage in
- collapse
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome
- granules
- cytotoxic granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gzmc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- apoptotic process
- killing of cells of other organism
Cellular Component
Where in the cell the gene product is active
- cytolytic granule
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase activity