PASK Gene Summary [Human]
This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Details
| Type | Protein Coding |
| Official Symbol | PASK |
| Official Name | PAS domain containing serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:17270] |
| Ensembl ID | ENSG00000115687 |
| Bio databases IDs | |
| Aliases | PAS domain containing serine/threonine kinase |
| Synonyms | DKFZp434O051, mKIAA0135, PAS domain containing serine/threonine kinase, PASKIN, STK37 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PASK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- PAS
- protein binding
- Protein kinase domain
- PAS fold
- phosphatidylinositol binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- PAS domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- lung squamous cell carcinoma
- squamous cell lung cancer
- plasma cell myeloma
- insulin resistance
role in cell
- phosphorylation in
- degradation in
- expression in
- serine phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- intracellular space
- cellular tail
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PASK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- negative regulation of glycogen biosynthetic process
- energy homeostasis
- protein autophosphorylation
- regulation of respiratory gaseous exchange
- protein phosphorylation
- regulation of glucagon secretion
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- phosphatidylinositol binding
- protein serine/threonine kinase activity