CCAR1 Gene Summary [Human]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; nuclear receptor coactivator activity; and transcription corepressor activity. Involved in positive regulation of cell migration and positive regulation of cell population proliferation. Acts upstream of or within positive regulation of apoptotic process. Located in nuclear envelope lumen. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CCAR1 |
| Official Name | cell division cycle and apoptosis regulator 1 [Source:HGNC Symbol;Acc:HGNC:24236] |
| Ensembl ID | ENSG00000060339 |
| Bio databases IDs | |
| Aliases | cell division cycle and apoptosis regulator 1 |
| Synonyms | 2610511G16Rik, 9430036H15Rik, CARP-1, cell division cycle and apoptosis regulator 1, DIS, LOC100911233, RGD1560358, uc.285+ |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCAR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- SAP motif
- DBC1
- nucleic acid binding
- SAP domain
- EF-hand domain pair
- transcription co-repressor
- LAIKA domain
- protein binding
- sequence-specific DNA binding
- BURAN domain
- double-stranded DNA binding
- S1-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by HIV-1
role in cell
- expression in
- proliferation
- apoptosis
- phosphorylation in
- survival
- migration
- differentiation
- binding in
- transcription in
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nucleoplasm
- perinuclear space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCAR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- positive regulation of cell proliferation
- apoptotic process
- positive regulation of apoptotic process
- positive regulation of cell migration
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- nuclear envelope lumen
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- transcription coactivator activity
- transcription corepressor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- ligand-dependent nuclear receptor transcription coactivator activity