PRORP Gene Summary [Human]
Enables ribonuclease P activity. Involved in mitochondrial tRNA 5'-end processing. Located in mitochondrion and nucleoplasm. Part of mitochondrial ribonuclease P complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PRORP |
| Official Name | protein only RNase P catalytic subunit [Source:HGNC Symbol;Acc:HGNC:19958] |
| Ensembl ID | ENSG00000100890 |
| Bio databases IDs | |
| Aliases | protein only RNase P catalytic subunit, mitochondrial RNase P subunit 3, proteinaceous RNase P |
| Synonyms | 1110008L16Rik, COXPD54, KIAA0391, mKIAA0391, MRPP3, protein only RNase P catalytic subunit, RGD1305089 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRORP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribonuclease P
- enzyme
- Protein-only RNase P
- PIN (PilT N terminus) domain: Superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- atopic dermatitis
- combined oxidative phosphorylation deficiency 54
- COVID-19
- Perrault syndrome type 1
- schizophrenia
- eczema
- leukoencephalopathy
- primary biliary cirrhosis
- breast carcinoma
role in cell
- autophagy in
- autophagy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial nucleoids
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRORP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA 5'-leader removal
Cellular Component
Where in the cell the gene product is active
- mitochondrial ribonuclease P complex
- mitochondrial matrix
- mitochondrion
- mitochondrial nucleoid
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ribonuclease P activity
- metal ion binding