Prorp Gene Summary [Mouse]
Predicted to enable ribonuclease P activity. Predicted to be involved in mitochondrial tRNA 5'-end processing and tRNA 5'-leader removal. Located in mitochondrial nucleoid. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 54. Orthologous to human PRORP (protein only RNase P catalytic subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prorp |
| Official Name | protein only RNase P catalytic subunit [Source:MGI Symbol;Acc:MGI:1913382] |
| Ensembl ID | ENSMUSG00000021023 |
| Bio databases IDs | |
| Aliases | protein only RNase P catalytic subunit |
| Synonyms | 1110008L16Rik, COXPD54, KIAA0391, mKIAA0391, MRPP3, protein only RNase P catalytic subunit, RGD1305089 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prorp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribonuclease P
- enzyme
- Protein-only RNase P
- PIN (PilT N terminus) domain: Superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- atopic dermatitis
- combined oxidative phosphorylation deficiency 54
- COVID-19
- Perrault syndrome type 1
- schizophrenia
- eczema
- leukoencephalopathy
- primary biliary cirrhosis
- breast carcinoma
role in cell
- autophagy in
- autophagy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial nucleoids
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prorp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA 5'-leader removal
Cellular Component
Where in the cell the gene product is active
- mitochondrial ribonuclease P complex
- mitochondrial matrix
- mitochondrion
- mitochondrial nucleoid
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ribonuclease P activity
- metal ion binding