POLI Gene Summary [Human]
The protein encoded by this gene is an error-prone DNA polymerase involved in DNA repair. The encoded protein promotes DNA synthesis across lesions in the template DNA, which other polymerases cannot do. The encoded polymerase inserts deoxynucleotides across lesions and then relies on DNA polymerase zeta to extend the nascent DNA strand to bypass the lesion. [provided by RefSeq, May 2017]
Details
| Type | Protein Coding |
| Official Symbol | POLI |
| Official Name | DNA polymerase iota [Source:HGNC Symbol;Acc:HGNC:9182] |
| Ensembl ID | ENSG00000101751 |
| Bio databases IDs | |
| Aliases | DNA polymerase iota |
| Synonyms | DNA POLYMERASE IOTA, DNA POLYMERASE ι, eta2, POL1, polymerase (DNA directed), iota, polymerase (DNA directed), ι, RAD30B, RAD3OB |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLI often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IMS family HHH motif
- Helix-hairpin-helix domain
- DNA-directed DNA polymerase
- catalytic domain
- UBM domain
- impB/mucB/samB family C-terminal domain
- enzyme
- protein binding
- impB/mucB/samB family
- Y-family of DNA polymerases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- lymphomagenesis
- asthma
- prostate cancer
- prostatic carcinoma
- seborrheic dermatitis
- lymphoma
- eczema
- psoriasis
role in cell
- cell death
- formation
- formation in
- phosphorylation in
- synthesis in
- double-stranded DNA break repair in
- ubiquitination in
- degradation in
- elongation in
- resolution in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoplasmic ribonucleoprotein granule
- nuclear foci
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLI gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA replication
- error-prone translesion synthesis
- translesion synthesis
Cellular Component
Where in the cell the gene product is active
- nuclear speck
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA-directed DNA polymerase activity
- protein binding
- metal ion binding
- damaged DNA binding