REV1 Gene Summary [Human]
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]
Details
| Type | Protein Coding |
| Official Symbol | REV1 |
| Official Name | REV1 DNA directed polymerase [Source:HGNC Symbol;Acc:HGNC:14060] |
| Ensembl ID | ENSG00000135945 |
| Bio databases IDs | |
| Aliases | REV1 DNA directed polymerase |
| Synonyms | 1110027I23Rik, AIBP80, REV1 DNA directed polymerase, REV1, DNA directed polymerase, REV1L |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human REV1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IMS family HHH motif
- BRCT
- Mad2 binding domain
- twin BRCT domain
- BRCT domain, a BRCA1 C-terminus domain
- Ubiquitin binding region
- enzyme
- protein binding
- impB/mucB/samB family
- deoxycytidyl transferase
- C-terminal domain of the Y-family polymerase Rev1
- damaged DNA binding
- BRCA1 C Terminus (BRCT) domain
- impB/mucB/samB family C-terminal domain
- breast cancer carboxy-terminal domain
- Y-family of DNA polymerases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- cholangiocarcinoma cancer
- uterine leiomyoma
- leiomyomatosis
- Huntington disease
- organismal death
- liver cancer
- lung adenocarcinoma
role in cell
- expression in
- growth
- proliferation
- survival
- synthesis in
- double-stranded DNA break repair
- DNA damage response
- senescence
- colony formation by
- scaffolding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human REV1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA replication
- error-prone translesion synthesis
- response to UV
- error-free translesion synthesis
Cellular Component
Where in the cell the gene product is active
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA-directed DNA polymerase activity
- protein binding
- metal ion binding
- deoxycytidyl transferase activity
- damaged DNA binding