SCML2 Gene Summary [Human]
This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which are involved in transcriptional repression. The encoded protein binds histone peptides that are monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development. [provided by RefSeq, Jun 2010]
Details
| Type | Protein Coding |
| Official Symbol | SCML2 |
| Official Name | Scm polycomb group protein like 2 [Source:HGNC Symbol;Acc:HGNC:10581] |
| Ensembl ID | ENSG00000102098 |
| Bio databases IDs | |
| Aliases | Scm polycomb group protein like 2 |
| Synonyms | 4932420G07Rik, RGD1564289, Scm polycomb group protein like 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SCML2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SLED domain
- Sterile alpha motif
- transcription regulator
- Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
- mbt repeat
- SAM (Sterile alpha motif )
- RNA binding Region
- protein binding
- malignant brain tumor (MBT) repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- apoptosis
- expression in
- growth
- ubiquitination in
- trimethylation in
- accumulation in
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- sex chromatin
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SCML2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- anatomical structure morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- PcG protein complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding
- chromatin binding