SCD Gene Summary [Human]
This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | SCD |
| Official Name | stearoyl-CoA desaturase [Source:HGNC Symbol;Acc:HGNC:10571] |
| Ensembl ID | ENSG00000099194 |
| Bio databases IDs | |
| Aliases | stearoyl-CoA desaturase, acyl-CoA desaturase, fatty acid desaturase, delta-9-desaturase |
| Synonyms | delta-9-desaturase, FADS5, hSCD1, MSTP008, PRO1933, SCD1, SCDOS, STEAROYL-COA DESATURASE, δ-9-desaturase |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SCD often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- stearoyl-CoA 9-desaturase
- Membrane-FADS-like
- oxidoreductase
- Fatty acid desaturase
- iron ion binding
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Alzheimer disease
- epithelial cancer
- atherosclerosis
- metastasis
- organismal death
- breast cancer
- pancreatic cancer
- liver cancer
- colorectal cancer
role in cell
- proliferation
- expression in
- cell death
- apoptosis
- binding in
- cell viability
- paclitaxel sensitivity
- replication in
- autophagy in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SCD gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- unsaturated fatty acid biosynthetic process
- response to fatty acid
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
- nucleolus
Molecular Function
What the gene product does at the molecular level
- stearoyl-CoA 9-desaturase activity
- protein binding
- oxidoreductase activity
- iron ion binding
- palmitoyl-CoA 9-desaturase activity