DNAJC3 Gene Summary [Human]
This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]
Details
| Type | Protein Coding |
| Official Symbol | DNAJC3 |
| Official Name | DnaJ heat shock protein family (Hsp40) member C3 [Source:HGNC Symbol;Acc:HGNC:9439] |
| Ensembl ID | ENSG00000102580 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member C3, interferon-induced, double-stranded RNA-activated protein kinase inhibitor, protein kinase inhibitor of 58 kDa, endoplasmic reticulum DNA J domain-containing protein 6 |
| Synonyms | 58kda Inhibitor Of RNA Activated Protein Kinase, AA408985, ACPHD, Dnajc3a, Dnajc3b, DnaJ heat shock protein family (Hsp40) member C3, DNJC3, ERdj6, HP58, LOC144871, LOC63880, mp58, P58, P58IPK, p58(IPK), Pkip58, PRKRI |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DNAJC3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DnaJ domain
- DnaJ
- DnaJ molecular chaperone homology domain
- protein kinase binding
- protein kinase inhibitor activity
- Tetratricopeptide repeats
- chaperone binding
- protein binding
- tetratricopeptide repeat
Pathways
Biological processes and signaling networks where the DNAJC3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- combined cerebellar and peripheral ataxia with hearing loss and diabetes mellitus
- hereditary disorder
- habitual abortion
- hyperglycemia
role in cell
- expression in
- growth
- blockade in
- phosphorylation in
- apoptosis
- number
- transformation
- abnormal morphology
- hypertrophy
- mass
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- azurophil granule lumen
- Extracellular Space
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum lumen
- microsome
- smooth endoplasmatic reticulum
- rough endoplasmic reticulum fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DNAJC3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- defense response to virus
- response to unfolded protein
- proteolysis involved in cellular protein catabolic process
- cellular response to cold
- protein folding in endoplasmic reticulum
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular vesicular exosome
- cytoplasm
- smooth endoplasmic reticulum
- membrane
- cytosol
- endoplasmic reticulum
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- chaperone binding
- protein kinase inhibitor activity
- misfolded protein binding