UGGT2 Gene Summary [Human]
UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | UGGT2 |
| Official Name | UDP-glucose glycoprotein glucosyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:15664] |
| Ensembl ID | ENSG00000102595 |
| Bio databases IDs | |
| Aliases | UDP-glucose glycoprotein glucosyltransferase 2, UDP-glucose:glycoprotein glucosyltransferase 2 |
| Synonyms | 1810064L21RIK, 3110001A05Rik, 3110027P15RIK, A230065J02RIK, AW047562, HUGT2, RGD1562426, RGD1563520, UDP-glucose glycoprotein glucosyltransferase 2, UGCGL2, UGGG2, UGT2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UGGT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- thioredoxin-like domain
- catalytic domain
- Glucosyltransferase 24
- UDP-glucose:glycoprotein glucosyltransferase
- enzyme
- protein binding
- glycosyltransferase family A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UGGT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein N-linked glycosylation via asparagine
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- macromolecular complex
- endoplasmic reticulum
- endoplasmic reticulum-Golgi intermediate compartment
Molecular Function
What the gene product does at the molecular level
- protein binding
- unfolded protein binding
- UDP-glucose:glycoprotein glucosyltransferase activity