LARP4B Gene Summary [Human]
This gene encodes a member of an evolutionarily conserved protein family implicated in RNA metabolism and translation. Members of this family are characterized by the presence of an La motif, which is often located adjacent to one or more RNA recognition motifs (RRM). Together, the two motifs constitute the functional region of the protein and enable its interaction with the RNA substrate. This protein family is divided into five sub-families: the genuine La proteins and four La-related protein (LARP) sub-families. The protein encoded by this gene belongs to LARP sub-family 4. It is a cytoplasmic protein that may play a stimulatory role in translation. [provided by RefSeq, Oct 2012]
Details
| Type | Protein Coding |
| Official Symbol | LARP4B |
| Official Name | La ribonucleoprotein 4B [Source:HGNC Symbol;Acc:HGNC:28987] |
| Ensembl ID | ENSG00000107929 |
| Bio databases IDs | |
| Aliases | La ribonucleoprotein 4B |
| Synonyms | A130023E24Rik, A630096F19, AI256361, D13Wsu64e, ENSMUSG00000120803, KIAA0217, La ribonucleoprotein 4B, LARP5, LOC107984285, RGD1310713, RP11 363N223 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LARP4B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- La domain
- mRNA 3' UTR binding
- RNA recognition motif
- La motif
- protein binding
- LA motif RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- prostate cancer
- chronic kidney disease
- COVID-19
- prostatic carcinoma
- pervasive developmental disorder
- atypical femur fracture
regulates
- luciferase
role in cell
- proliferation
- synthesis in
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- cytosol
- nucleoli
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LARP4B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- membrane
- cytosol
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- mRNA 3'-UTR binding