ZNHIT6 Gene Summary [Human]
Enables ATPase binding activity; TFIID-class transcription factor complex binding activity; and identical protein binding activity. Involved in box C/D snoRNP assembly; protein complex oligomerization; and snoRNA localization. Located in extracellular exosome. Part of pre-snoRNP complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZNHIT6 |
| Official Name | zinc finger HIT-type containing 6 [Source:HGNC Symbol;Acc:HGNC:26089] |
| Ensembl ID | ENSG00000117174 |
| Bio databases IDs | |
| Aliases | zinc finger HIT-type containing 6, box C/D snoRNA essential 1 homolog (S. cerevisiae) |
| Synonyms | 2410019A14Rik, BCD1, BREAST CANCER ANTIGEN NY-BR-75, C1orf181, NY-BR-75, RGD1308723, zinc finger, HIT type 6, zinc finger HIT-type containing 6, zinc finger, HIT-type containing 6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZNHIT6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase binding
- zinc finger HIT (zf-HIT) domain
- binding protein
- enzyme binding
- transcription factor binding
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZNHIT6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- snoRNA localization
- box C/D snoRNP assembly
- protein oligomerization
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- pre-snoRNP complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding
- TFIID-class transcription factor binding
- enzyme binding
- ATPase binding