SCG3 Gene Summary [Human]
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | SCG3 |
| Official Name | secretogranin III [Source:HGNC Symbol;Acc:HGNC:13707] |
| Ensembl ID | ENSG00000104112 |
| Bio databases IDs | |
| Aliases | secretogranin III |
| Synonyms | 1B1075, Chgd, SECRETOGRANIN III, Sg3, SGIII |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SCG3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Secretogranin-3
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- small cell lung cancer
- weight gain
- choroidal neovascularization
role in cell
- expression in
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- perinuclear Golgi regions
- cellular membrane
- secretory granule membrane
- endoplasmic reticulum lumen
- secretory granules
- membrane processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SCG3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization in secretory granule
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- secretory granule membrane
- transport vesicle membrane
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding