NCAM2 Gene Summary [Human]
The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NCAM2 |
| Official Name | neural cell adhesion molecule 2 [Source:HGNC Symbol;Acc:HGNC:7657] |
| Ensembl ID | ENSG00000154654 |
| Bio databases IDs | |
| Aliases | neural cell adhesion molecule 2 |
| Synonyms | NCAM21, neural cell adhesion molecule 2, Ocam, OCAM-GPI, RNCAM |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NCAM2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- FN3
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- Purple acid Phosphatase, N-terminal domain
- Immunoglobulin I-set domain
- Fibronectin type 3 domain
- identical protein binding
- Immunoglobulin V-set domain
- T-cell surface glycoprotein CD3 delta chain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- Alzheimer disease
- endometrial carcinoma
- epithelial endometrial cancer
- insulin resistance
- rotator cuff injury
- Down syndrome
- obesity
- allergy
- alcoholism
regulates
- SRC (family)
- CaMKII
role in cell
- activation in
- outgrowth
- development
- calcium spike in
- branching in
- branching
- outgrowth in
- density
- cell-cell adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- synaptic membrane
- nuclear bodies
- growth cone
- neurites
- axons
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NCAM2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron cell-cell adhesion
- axonal fasciculation
Cellular Component
Where in the cell the gene product is active
- nuclear body
- membrane
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding