SNX16 Gene Summary [Human]
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The protein encoded by this gene associates with late endosome membranes as is involved in tubule formation, cholesterol transport, and transport of tetraspanin CD81. The encoded protein also inhibits cell migration and tumorigenesis. [provided by RefSeq, Jan 2017]
Details
| Type | Protein Coding |
| Official Symbol | SNX16 |
| Official Name | sorting nexin 16 [Source:HGNC Symbol;Acc:HGNC:14980] |
| Ensembl ID | ENSG00000104497 |
| Bio databases IDs | |
| Aliases | sorting nexin 16 |
| Synonyms | 4930522N22Rik, sorting nexin 16 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SNX16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil domain
- The Phox Homology domain, a phosphoinositide binding module
- identical protein binding
- phosphatidylinositol binding
- PX domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- endosomal membrane
- early endosomes
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SNX16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- early endosome to late endosome transport
- endosome to lysosome transport
- protein targeting to lysosome
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- late endosome membrane
- early endosome
- intracellular membrane-bounded organelle
- late endosome
- endosome membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- phosphatidylinositol binding