MED25 Gene Summary [Human]
This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. [provided by RefSeq, Apr 2010]
Details
| Type | Retained Intron |
| Official Symbol | MED25 |
| Official Name | mediator complex subunit 25 [Source:HGNC Symbol;Acc:HGNC:28845] |
| Ensembl ID | ENSG00000104973 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 25 |
| Synonyms | 2610034E13Rik, 2610529E18Rik, ACID1, ARC92, BVSYS, CMT2B2, ESTM2, mediator complex subunit 25, MGI:1922863, P78, PTOV2, RGD1305137, TCBAP0758 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MED25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- VP16 activation domain
- retinoic acid receptor binding
- Mediator complex subunit 25 C-terminal NR box-containing
- Mediator complex subunit 25 PTOV activation and synapsin 2
- Domain of unknown function (DUF4371)
- transcription factor binding
- retinoid X receptor binding
- protein binding
- Mediator complex subunit 25 synapsin 1
- Mediator complex subunit 25 von Willebrand factor type A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- allergic rhinitis
- hereditary disorder
- Basel-Vanagaite-Smirin-Yosef syndrome
- Charcot-Marie-Tooth disease type 2
- neurodevelopmental disorder
- Charcot-Marie-Tooth disease axonal type 2B2
role in cell
- proliferation
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MED25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of chromatin binding
- positive regulation of transcription initiation from RNA polymerase II promoter
- negative regulation of fibroblast proliferation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of mediator complex assembly
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- core mediator complex
- mediator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- retinoic acid receptor binding
- retinoid X receptor binding
- transcription coactivator binding