MED23 Gene Summary [Human]
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012]
Details
| Type | Protein Coding |
| Official Symbol | MED23 |
| Official Name | mediator complex subunit 23 [Source:HGNC Symbol;Acc:HGNC:2372] |
| Ensembl ID | ENSG00000112282 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 23 |
| Synonyms | 3000002A17Rik, ARC130, CRSP130, CRSP133, CRSP3, DRIP130, ESTM7, KIAA1216, Med130, mediator complex subunit 23, mKIAA1216, MRT18, sno, snouty, SUR-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MED23 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- ubiquitin protein ligase activity
- protein binding
- Mediator complex subunit 23
Pathways
Biological processes and signaling networks where the MED23 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- autosomal recessive mental retardation type 18
- non-insulin-dependent diabetes mellitus
- autosomal recessive mental retardation type 18 with epilepsy
- mental retardation
- neurodevelopmental disorder
- growth failure
- hyperargininemia
- autosomal recessive mental retardation type 18 without epilepsy
- hereditary disorder
regulated by
- beta-estradiol
- tretinoin
- wrenchnolol
- geldanamycin
- interferon alpha
- MED24
- tetrachlorodibenzodioxin
role in cell
- extravasation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MED23 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- positive regulation of gene expression
- positive regulation of T cell extravasation
- regulation of transcription, DNA-dependent
- transcription initiation from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- core mediator complex
- mediator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity