Med25 Gene Summary [Mouse]
Enables nuclear retinoid X receptor binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in central nervous system; incisor; submandibular gland primordium; and tail dorsal root ganglion. Orthologous to human MED25 (mediator complex subunit 25). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Med25 |
| Official Name | mediator complex subunit 25 [Source:MGI Symbol;Acc:MGI:1922863] |
| Ensembl ID | ENSMUSG00000002968 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 25 |
| Synonyms | 2610034E13Rik, 2610529E18Rik, ACID1, ARC92, BVSYS, CMT2B2, ESTM2, mediator complex subunit 25, MGI:1922863, P78, PTOV2, RGD1305137, TCBAP0758 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Med25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- VP16 activation domain
- retinoic acid receptor binding
- Mediator complex subunit 25 C-terminal NR box-containing
- Mediator complex subunit 25 PTOV activation and synapsin 2
- Domain of unknown function (DUF4371)
- transcription factor binding
- retinoid X receptor binding
- protein binding
- Mediator complex subunit 25 synapsin 1
- Mediator complex subunit 25 von Willebrand factor type A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- allergic rhinitis
- hereditary disorder
- Basel-Vanagaite-Smirin-Yosef syndrome
- Charcot-Marie-Tooth disease type 2
- neurodevelopmental disorder
- Charcot-Marie-Tooth disease axonal type 2B2
regulates
- RNA polymerase II
- DNA promoter
- DNA endogenous promoter
- MMP1
- MED25
- Vp16
role in cell
- proliferation
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Med25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of chromatin binding
- positive regulation of transcription initiation from RNA polymerase II promoter
- negative regulation of fibroblast proliferation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of mediator complex assembly
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- core mediator complex
- mediator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- retinoic acid receptor binding
- retinoid X receptor binding
- transcription coactivator binding