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MED30
MED30 Gene Summary
The multiprotein TRAP/Mediator complex facilitates gene expression through a wide variety of transcriptional activators. MED30 is a component of this complex that appears to be metazoan specific (Baek et al., 2002 [PubMed 11909976]).[supplied by OMIM, Nov 2010]
Details
| Type | Protein Coding |
| Official Symbol | MED30 |
| Official Name | mediator complex subunit 30 [Source:HGNC Symbol;Acc:HGNC:23032] |
| Ensembl ID | ENSG00000164758 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 30 |
| Synonyms | 1810038N03Rik,2510044J04Rik,MED30S,mediator complex subunit 30,THRAP6,TRAP25 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mediator complex subunit 30
- transcription regulator
- transcription co-activator
- ubiquitin protein ligase activity
- transcription cofactor
- protein binding
- thyroid hormone receptor binding
Pathways
Biological processes and signaling networks where the MED30 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- MED26
- POLR2A
- MED20
- MED13
- MED19
- CDK8
- MED4
- ACAD11
- EHMT2
- DOCK8
disease
- cardiomyopathy
- adenoid cystic carcinoma of salivary gland
- salivary gland cancer
- epithelial cancer
- salivary gland mucoepidermoid carcinoma
- salivary duct carcinoma
- salivary duct cancer
- hepatocellular carcinoma
- liver cancer
- Kawasaki disease
regulated by
- CCND1
- CDK4
- mir-146 (includes others)
regulates
- SDHC
- PPARGC1A
- NDUFB3
- FOXP3
- NDUFA10
- LPL
- COX10
- NDUFS2
- SDHB
- COX6A2
role in cell
- transactivation in
- expression in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the MED30 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- somatic stem cell maintenance
- protein ubiquitination
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- core mediator complex
- ubiquitin ligase complex
- mediator complex
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- transcription cofactor activity
- transcription coactivator activity
- ligand-dependent nuclear receptor transcription coactivator activity
- vitamin D receptor binding
- thyroid hormone receptor binding