RASAL3 Gene Summary [Human]
This gene belongs to the Ras GTPase-activating proteins (RasGAP) family and encodes a protein with pleckstrin homology (PH), C2, and Ras GTPase-activation protein (RasGAP) domains. This protein is localized near or at the plasma membrane when expressed exogenously. Reduced expression of this gene in some cell lines resulted in increased levels of the active form of Ras (Ras-GTP), suggesting that this gene may play a role in negatively regulating the Ras signaling pathway. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
Details
| Type | Protein Coding |
| Official Symbol | RASAL3 |
| Official Name | RAS protein activator like 3 [Source:HGNC Symbol;Acc:HGNC:26129] |
| Ensembl ID | ENSG00000105122 |
| Bio databases IDs | |
| Aliases | RAS protein activator like 3 |
| Synonyms | A430107D22Rik, RAS protein activator like 3, RGD1309019 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RASAL3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ras GTPase Activating Domain
- GTPase-activator protein for Ras-like GTPases
- coiled-coil domain 1 of SUN domain-containing proteins
- GTPase-activator protein for Ras-like GTPase
- protein binding
- Pleckstrin homology-like domain
- Cell division protein ZapB
- identical protein binding
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- liver damage
- dextran sodium sulfate-induced colitis
- lung adenocarcinoma
- lung adenocarcinoma formation
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
role in cell
- phosphorylation in
- number
- cellular infiltration by
- production in
- motility
- migration
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RASAL3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of Ras protein signal transduction
- positive regulation of NK T cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cell cortex
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- GTPase activator activity