CACTIN Gene Summary [Human]
Enables RNA binding activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of cytokine production; and negative regulation of signal transduction. Located in cytosol and nuclear speck. Part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CACTIN |
| Official Name | cactin, spliceosome C complex subunit [Source:HGNC Symbol;Acc:HGNC:29938] |
| Ensembl ID | ENSG00000105298 |
| Bio databases IDs | |
| Aliases | cactin, spliceosome C complex subunit, NY REN 24 antigen, functional spliceosome-associated protein c, cactin homolog (Drosophila) |
| Synonyms | 2510012J08Rik, C19orf29, cactin, spliceosome C complex subunit, fSAPc, LOC58509, NY-REN-24, RGD1563634 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CACTIN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cactus-binding C-terminus of cactin protein
- nuclear localization sequence
- protein binding
- Conserved mid region of cactin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CACTIN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of toll-like receptor signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- negative regulation of innate immune response
- nuclear mRNA splicing, via spliceosome
- nuclear mRNA cis splicing, via spliceosome
- cellular response to lipopolysaccharide
- negative regulation of protein phosphorylation
- innate immune response
- negative regulation of interleukin-8 production
- cellular response to interleukin-1
- cellular response to tumor necrosis factor
- negative regulation of tumor necrosis factor production
- negative regulation of lipopolysaccharide-mediated signaling pathway
- negative regulation of interferon-beta production
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- cytoplasm
- nuclear speck
- spliceosomal complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding