SPATA2 Gene Summary [Human]
Enables signaling receptor complex adaptor activity and ubiquitin-specific protease binding activity. Involved in several processes, including protein deubiquitination; regulation of necroptotic process; and regulation of tumor necrosis factor-mediated signaling pathway. Located in cytoplasm; fibrillar center; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SPATA2 |
| Official Name | spermatogenesis associated 2 [Source:HGNC Symbol;Acc:HGNC:14681] |
| Ensembl ID | ENSG00000158480 |
| Bio databases IDs | |
| Aliases | spermatogenesis associated 2, protein phosphatase 1, regulatory subunit 145 |
| Synonyms | mKIAA0757, PD1, PPP1R145, spermatogenesis associated 2, tamo |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SPATA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- B-box-type zinc finger superfamily
- binding protein
- protease binding
- receptor signaling complex scaffold protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
role in cell
- expression in
- cell death
- activation in
- apoptosis
- phosphorylation in
- binding in
- degradation in
- recruitment
- production in
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- fibrillar center
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SPATA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- necroptosis
- seminiferous tubule development
- spermatogenesis
- regulation of tumor necrosis factor-mediated signaling pathway
- regulation of inflammatory response
- regulation of necroptosis
- protein K63-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor signaling complex scaffold activity