EI24 Gene Summary [Human]
This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]
Details
| Type | Protein Coding |
| Official Symbol | EI24 |
| Official Name | EI24 autophagy associated transmembrane protein [Source:HGNC Symbol;Acc:HGNC:13276] |
| Ensembl ID | ENSG00000149547 |
| Bio databases IDs | |
| Aliases | EI24 autophagy associated transmembrane protein, ectopic P-granules autophagy protein 4 homolog (C. elegans) |
| Synonyms | EI24 autophagy associated transmembrane protein, EI24, autophagy associated transmembrane protein, EPG4, etoposide induced 2.4 mRNA, PIG8, TP53I8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EI24 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IBB-like domain
- Etoposide-induced protein 2.4 (EI24)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- early-onset breast cancer
- abdominal aortic aneurysm
- tubulo-interstitial fibrosis
- hepatomegaly
- neurological disorder
- demyelination
- mental retardation
role in cell
- activation in
- apoptosis
- hypertrophy
- growth
- binding in
- loss
- cell death
- inactivation in
- autophagy
- vacuolation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EI24 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell growth
- apoptotic process
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear membrane
- membrane
- cytosol
- Golgi apparatus
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding