EPHB6 Gene Summary [Human]
This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | EPHB6 |
| Official Name | EPH receptor B6 [Source:HGNC Symbol;Acc:HGNC:3396] |
| Ensembl ID | ENSG00000106123 |
| Bio databases IDs | |
| Aliases | EPH receptor B6 |
| Synonyms | Cekl, EPHB5, EPH receptor B6, HEP, LOC102554290, Mep |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EPHB6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ligand Binding Domain of Ephrin Receptors
- Protein kinase (unclassified specificity)
- signaling receptor activity
- Tyrosine-protein kinase ephrin type A/B receptor-like
- Protein tyrosine and serine/threonine kinase
- SAM (Sterile alpha motif )
- Purple acid Phosphatase, N-terminal domain
- ephrin receptor
- protein binding
- Fibronectin type 3 domain
- protein-tyrosine kinase
- Protein kinase domain
- Tumor necrosis factor receptor superfamily (TNFRSF)
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Sterile alpha motif
- Protein Kinases, catalytic domain
- Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
- FN3
- SAM domain (Sterile alpha motif)
- Tyrosine kinase, catalytic domain
- Ephrin receptor ligand binding domain
Pathways
Biological processes and signaling networks where the EPHB6 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cutaneous melanoma
- experimental autoimmune encephalomyelitis
- lung adenocarcinoma
- lung adenocarcinoma formation
- cutaneous melanoma cancer
- delayed hypersensitive reaction
- metastasis
- renal clear cell adenocarcinoma
- renal clear cell cancer
- non-small cell lung carcinoma
role in cell
- expression in
- proliferation
- apoptosis
- phosphorylation in
- growth
- maturation
- invasiveness
- cell spreading
- migration
- signaling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EPHB6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ephrin receptor signaling pathway
- axon guidance
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytosol
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- signaling receptor activity
- ephrin receptor activity
- transmembrane-ephrin receptor activity