EFNB2 Gene Summary [Human]
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | EFNB2 |
| Official Name | ephrin B2 [Source:HGNC Symbol;Acc:HGNC:3227] |
| Ensembl ID | ENSG00000125266 |
| Bio databases IDs | |
| Aliases | ephrin B2, HTK ligand, ligand of eph-related kinase 5, eph-related receptor tyrosine kinase ligand 5 |
| Synonyms | ELF-2, ephrin B2, Epl5, EPLG5, HTKL, LERK-5, NLERK-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EFNB2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- extracellular domain
- Ephrin
- Cupredoxin superfamily
- cytoplasmic domain
- ectodomain
- intracellular domain
- ephrin receptor binding
- protein binding
- receptor binding
- cytosolic tail domain
Pathways
Biological processes and signaling networks where the EFNB2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- metastasis
- advanced cancer
- malignant thyroid gland neoplasm
- thyroid cancer
- colorectal cancer
- growth failure
- prostate cancer
- papillary thyroid carcinoma
role in cell
- phosphorylation in
- expression in
- activation in
- apoptosis
- growth
- proliferation
- migration
- cell death
- quantity
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- cellular membrane
- presynaptic membrane
- synaptic membrane
- synapse
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EFNB2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- keratinocyte proliferation
- adherens junction organization
- T cell costimulation
- positive regulation of cell proliferation
- cell-cell signaling
- venous blood vessel morphogenesis
- axon guidance
- blood vessel morphogenesis
- cell migration involved in sprouting angiogenesis
- anatomical structure morphogenesis
- cell adhesion
- organ morphogenesis
- positive regulation of cardiac muscle cell differentiation
- negative regulation of keratinocyte proliferation
- negative regulation of neuron projection development
- nephric duct morphogenesis
- lymph vessel development
- ephrin receptor signaling pathway
- regulation of chemotaxis
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- adherens junction
- focal adhesion
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ephrin receptor binding
- viral receptor activity