BCL7B Gene Summary [Human]
This gene encodes a member of the BCL7 family including BCL7A, BCL7B and BCL7C proteins. This member is BCL7B, which contains a region that is highly similar to the N-terminal segment of BCL7A or BCL7C proteins. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. This gene is located at a chromosomal region commonly deleted in Williams syndrome. This gene is highly conserved from C. elegans to human. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2010]
Details
| Type | Retained Intron |
| Official Symbol | BCL7B |
| Official Name | BAF chromatin remodeling complex subunit BCL7B [Source:HGNC Symbol;Acc:HGNC:1005] |
| Ensembl ID | ENSG00000106635 |
| Bio databases IDs | |
| Aliases | BAF chromatin remodeling complex subunit BCL7B |
| Synonyms | BAF chromatin remodeling complex subunit BCL7B, B cell CLL/lymphoma 7B, LOC100040069, LOC100048278, SMARCJ2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BCL7B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BCL7, N-terminal conserver region
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BCL7B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitotic metaphase/anaphase transition
- positive regulation of cell proliferation
- regulation of nucleotide-excision repair
- regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- negative regulation of cell differentiation
- apoptotic process
- cell differentiation
- Wnt receptor signaling pathway
- regulation of G1/S transition of mitotic cell cycle
- positive regulation of double-strand break repair
- regulation of G0 to G1 transition
Cellular Component
Where in the cell the gene product is active
- SWI/SNF complex
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding