TNKS2 Gene Summary [Human]
Enables NAD+ ADP-ribosyltransferase activity; enzyme binding activity; and protein ADP-ribosylase activity. Involved in several processes, including protein ADP-ribosylation; protein localization to chromosome, telomeric region; and regulation of telomere maintenance. Located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TNKS2 |
| Official Name | tankyrase 2 [Source:HGNC Symbol;Acc:HGNC:15677] |
| Ensembl ID | ENSG00000107854 |
| Bio databases IDs | |
| Aliases | tankyrase 2, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 |
| Synonyms | 5430432P15RIK, AA517131, AI662480, ARTD6, LOC100910717, PARP-5b, PARP-5c, pART6, TANK2, tankyrase 2, tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, TNKL |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNKS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ankyrin repeats (many copies)
- NAD ADP-ribosyltransferase
- SAM (Sterile alpha motif )
- SAM domain
- Poly(ADP-ribose) polymerase catalytic domain
- Ankyrin repeats (3 copies)
- enzyme binding
- enzyme
- protein binding
- ADP_ribosyl
- Ankyrin repeat
- Sterile alpha motif
- pentosyltransferase
- SAM domain (Sterile alpha motif)
- ankyrin repeats
Pathways
Biological processes and signaling networks where the TNKS2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hematological neoplasia
- myeloid/lymphoid neoplasm with eosinophilia
- non-insulin-dependent diabetes mellitus
- colon carcinoma
- colon epithelial cancer
regulated by
- lipopolysaccharide
- HIF1AN
- mir-17 (includes others)
- 293 cells
- methylprednisolone
- XAV939
role in cell
- growth
- cell death
- degradation in
- phosphorylation in
- proliferation
- number
- signaling in
- transcription in
- ubiquitination in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- high-density microsomal fractions
- low-density microsomal fraction
- Cytoplasm
- perinuclear region
- pericentriolar regions
- centrosome
- Golgi Apparatus
- cytosol
- nuclear pores
- nuclear envelope
- telomeres
- Golgi vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNKS2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- protein localization to chromosome, telomeric region
- positive regulation of telomere maintenance via telomerase
- positive regulation of canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway
- protein poly-ADP-ribosylation
- protein auto-ADP-ribosylation
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- chromosome, telomeric region
- nucleus
- pericentriolar material
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- nucleotidyltransferase activity
- protein binding
- metal ion binding
- enzyme binding
- NAD+ ADP-ribosyltransferase activity