DCTN4 Gene Summary [Human]
Enables protein N-terminus binding activity. Located in centrosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DCTN4 |
| Official Name | dynactin subunit 4 [Source:HGNC Symbol;Acc:HGNC:15518] |
| Ensembl ID | ENSG00000132912 |
| Bio databases IDs | |
| Aliases | dynactin subunit 4 |
| Synonyms | 1110001K06Rik, 4930547K17Rik, C130039E17RIK, DYN4, dynactin 4, dynactin subunit 4, P62 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DCTN4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dynactin p62 family
- protein binding
Pathways
Biological processes and signaling networks where the DCTN4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- cholangiocarcinoma
- cholangiocarcinoma cancer
- lung adenocarcinoma formation
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
role in cell
- morphology
- translocation
- binding
- binding in
- translocation in
- motor function in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- focal adhesions
- actin cytoskeleton
- centrosome
- microtubules
- cytosol
- spindle pole
- actin stress fibers
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DCTN4 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- spindle pole
- kinetochore
- nucleus
- centrosome
- cytoplasmic dynein complex
- focal adhesion
- cytoplasm
- dynactin complex
- cell cortex
- stress fiber
- cytosol
- sarcomere
Molecular Function
What the gene product does at the molecular level
- protein binding