Larp4b Gene Summary [Mouse]
Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in positive regulation of 3'-UTR-mediated mRNA stabilization and positive regulation of translation. Predicted to be located in nucleolus. Predicted to be active in cytoplasmic stress granule and cytosol. Is expressed in embryo; extraembryonic component; and vertebral axis musculature. Orthologous to human LARP4B (La ribonucleoprotein 4B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Larp4b |
| Official Name | La ribonucleoprotein domain family, member 4B [Source:MGI Symbol;Acc:MGI:106330] |
| Ensembl ID | ENSMUSG00000033499 |
| Bio databases IDs | |
| Aliases | La ribonucleoprotein domain family, member 4B |
| Synonyms | A130023E24Rik, A630096F19, AI256361, D13Wsu64e, ENSMUSG00000120803, KIAA0217, La ribonucleoprotein 4B, LARP5, LOC107984285, RGD1310713, RP11 363N223 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Larp4b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- La domain
- mRNA 3' UTR binding
- RNA recognition motif
- La motif
- protein binding
- LA motif RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- prostate cancer
- chronic kidney disease
- COVID-19
- prostatic carcinoma
- pervasive developmental disorder
- atypical femur fracture
regulates
- luciferase
role in cell
- proliferation
- synthesis in
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- cytosol
- nucleoli
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Larp4b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- membrane
- cytosol
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- mRNA 3'-UTR binding