MEX3B Gene Summary [Human]
This gene encodes an RNA-binding phosphoprotein that is part of the MEX3 (muscle excess 3) family of translational regulators. The encoded protein contains N-terminal nuclear export and nuclear localization signals and is exported from the cytoplasm to the nucleus. The protein binds to RNA via two KH domains and also colocalizes with MEX3A, Dcp1A decapping factor and Argonaute proteins within P (processing) bodies. [provided by RefSeq, Oct 2012]
Details
| Type | Protein Coding |
| Official Symbol | MEX3B |
| Official Name | mex-3 RNA binding family member B [Source:HGNC Symbol;Acc:HGNC:25297] |
| Ensembl ID | ENSG00000183496 |
| Bio databases IDs | |
| Aliases | mex-3 RNA binding family member B |
| Synonyms | 4931439A04Rik, M-04814, mex-3 RNA binding family member B, mKIAA2009, RKHD3, RNF195 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MEX3B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- K homology (KH) RNA-binding domain, type I
- KH domain
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- calcium ion binding
- protein binding
- K homology RNA-binding domain
- Zinc finger, C3HC4 type (RING finger)
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MEX3B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein autophosphorylation
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasmic mRNA processing body
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- calcium ion binding