DHX58 Gene Summary [Human]
Enables double-stranded RNA binding activity; single-stranded RNA binding activity; and zinc ion binding activity. Involved in negative regulation of defense response and negative regulation of type I interferon production. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | DHX58 |
| Official Name | DExH-box helicase 58 [Source:HGNC Symbol;Acc:HGNC:29517] |
| Ensembl ID | ENSG00000108771 |
| Bio databases IDs | |
| Aliases | DExH-box helicase 58, RNA helicase LGP2 |
| Synonyms | B430001I08Rik, D11LGP2, D11Lgp2e, DEXH-box helicase 58, LGP2, LPG2, RGD1310093, RLR-3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DHX58 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DEAD/DEAH box helicase
- enzyme
- protein binding
- ATPase
- Helicase conserved C-terminal domain
- single-stranded RNA binding
- RNA helicase
- helicase domain
- transcription repression domain
- IP3-binding suppressor domain
- zinc ion binding
- RLR_C_like
- Type III restriction enzyme, res subunit
- double-stranded RNA binding
- N-terminal helicase domain of the DEAD-box helicase superfamily
- RIG-I receptor C-terminal domain
- helicase_insert_domain
- DEAD-like helicases superfamily
- C-terminal domain of RIG-I
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the DHX58 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atresia
- systemic lupus erythematosus
- coronary artery disease
- infection by Picornaviridae
- infection by Flaviviridae
role in cell
- activation in
- apoptosis
- induction in
- growth
- sensing in
- self-association in
- replication in
- dimerization in
- antiviral response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular compartment
- intracellular space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DHX58 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of type I interferon production
- cytoplasmic pattern recognition receptor signaling pathway
- response to bacterium
- negative regulation of MDA-5 signaling pathway
- positive regulation of type I interferon production
- regulation of innate immune response
- positive regulation of MDA-5 signaling pathway
- positive regulation of RIG-I signaling pathway
- response to virus
- negative regulation of RIG-I signaling pathway
- negative regulation of innate immune response
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- DNA binding
- ATP binding
- zinc ion binding
- protein binding
- RNA helicase activity
- double-stranded RNA binding
- single-stranded RNA binding