UGDH Gene Summary [Human]
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | UGDH |
| Official Name | UDP-glucose 6-dehydrogenase [Source:HGNC Symbol;Acc:HGNC:12525] |
| Ensembl ID | ENSG00000109814 |
| Bio databases IDs | |
| Aliases | UDP-glucose 6-dehydrogenase |
| Synonyms | DEE84, EIEE84, GDH, UDGH, UDPGDH, UDP-GlcDH, UDP-glucose 6-dehydrogenase, UDP-glucose dehydrogenase, UGD |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UGDH often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
- Rossmann-fold NAD(P)(+)-binding proteins
- UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
- UDPglucose 6-dehydrogenase
- nucleotide sugar dehydrogenase
- enzyme
- UDP binding domain
- identical protein binding
- UDP-glucose/GDP-mannose dehydrogenase family, central domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- COVID-19
- early infantile epileptic encephalopathy type 84
- neoplasia
- congenital heart disease
- peripheral arterial disease
- idiopathic scoliosis
- MELAS syndrome
- liver damage
- hereditary disorder
role in cell
- production in
- proliferation
- apoptosis
- expression in
- migration
- binding
- accumulation in
- colony formation by
- invasion
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UGDH gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chondroitin sulfate biosynthetic process
- heparan sulfate proteoglycan biosynthetic process
- UDP-glucuronate biosynthetic process
- gastrulation with mouth forming second
- glycosaminoglycan biosynthetic process
- protein hexamerization
- neuron development
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- NAD binding
- UDP-glucose 6-dehydrogenase activity