P3H3 Gene Summary [Human]
The protein encoded by this gene belongs to the leprecan family of proteoglycans, which function as collagen prolyl hydroxylases that are required for proper collagen biosynthesis, folding and assembly. This protein, like other family members, is thought to reside in the endoplasmic reticulum. Epigenetic inactivation of this gene is associated with breast and other cancers, suggesting that it may function as a tumor suppressor. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | P3H3 |
| Official Name | prolyl 3-hydroxylase 3 [Source:HGNC Symbol;Acc:HGNC:19318] |
| Ensembl ID | ENSG00000110811 |
| Bio databases IDs | |
| Aliases | prolyl 3-hydroxylase 3, procollagen-proline 3-dioxygenase |
| Synonyms | GRCB, HSU47926, LEPREL2, prolyl 3-hydroxylase 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human P3H3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- protein binding
- 2OG-Fe(II) oxygenase superfamily
- Prolyl 4-hydroxylase alpha subunit homologues
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human P3H3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-lysine hydroxylation
- negative regulation of cell proliferation
- collagen biosynthetic process
- collagen metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- L-ascorbic acid binding
- iron ion binding
- procollagen-proline 3-dioxygenase activity