RTN4R Gene Summary [Human]
This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RTN4R |
| Official Name | reticulon 4 receptor [Source:HGNC Symbol;Acc:HGNC:18601] |
| Ensembl ID | ENSG00000040608 |
| Bio databases IDs | |
| Aliases | reticulon 4 receptor, NOGO receptor |
| Synonyms | NGR, NGR1, NOGO66, NOGOR, reticulon 4 receptor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RTN4R often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- extracellular domain
- Leucine-rich repeats, typical (most populated) subfamily
- sphingolipid binding
- lipid binding
- protein phosphatase 1 regulatory subunit 42
- signaling receptor activity
- ectodomain
- Leucine rich repeat
- signal peptide
- protein binding
- Leucine Rich repeats (2 copies)
- glycosaminoglycan binding
- leucine-rich repeat
- binding protein
- stalk region
- transmembrane domain
- heparin binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the RTN4R gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- Alzheimer disease
- motor dysfunction
- susceptibility to schizophrenia
- global developmental delay with intellectual disability
- heat hyperalgesia
role in cell
- expression in
- apoptosis
- phosphorylation in
- activation in
- inhibition
- number
- growth
- binding
- regeneration
- regrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- fimbria
- glutaminergic synapse
- axon component
- presynaptic regions
- cell surface
- Extracellular Space
- cellular membrane
- Endoplasmic Reticulum
- Mitochondria
- microtubules
- plasma membrane extracellular face
- presynaptic membrane
- postsynaptic membrane
- plasma membrane projections
- synaptic vesicles
- growth cone
- neurites
- dendritic trees
- membrane rafts
- membrane processes
- perikaryon
- axons
- postsynaptic density
- presynaptic terminals
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RTN4R gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of axon regeneration
- positive regulation of Rho protein signal transduction
- negative regulation of neuron projection development
- negative regulation of axon extension
- axonogenesis
- neuronal signal transduction
- cell surface receptor signaling pathway
- positive regulation of GTPase activity
- corpus callosum development
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- axonal growth cone
- dendritic shaft
- membrane raft
- external side of plasma membrane
- endoplasmic reticulum
- neuronal cell body
- perikaryon
- neuron projection
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- chondroitin sulfate binding
- protein binding
- neuregulin receptor activity
- signaling receptor activity
- heparin binding