RBMS1 Gene Summary [Human]
This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. Several transcript variants, resulting from alternative splicing and encoding different isoforms, have been described. A pseudogene for this locus is found on chromosome 12. [provided by RefSeq, Feb 2009]
Details
| Type | Processed Transcript |
| Official Symbol | RBMS1 |
| Official Name | RNA binding motif single stranded interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:9907] |
| Ensembl ID | ENSG00000153250 |
| Bio databases IDs | |
| Aliases | RNA binding motif single stranded interacting protein 1, suppressor of cdc 2 (cdc13) with RNA binding motif 2, c-myc gene single strand binding protein 2 |
| Synonyms | 2600014B10Rik, C2ORF12, HCC-4, MSSP, MSSP-1, MSSP-2, MSSP-3, RNA binding motif single stranded interacting protein 1, RNA binding MOTIF, SINGLE-STRANDED INTERACTING protein 1, SCR2, YC1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RBMS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- rheumatoid arthritis
- non-insulin-dependent diabetes mellitus
- irritable bowel syndrome
- chronic obstructive pulmonary disease
- growth failure
- refractive error
- uterine leiomyoma
- leiomyomatosis
- breast adenocarcinoma
role in cell
- expression in
- replication in
- glycosylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RBMS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA replication
- RNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- poly(A) RNA binding
- double-stranded DNA binding
- poly(U) RNA binding
- single-stranded DNA binding
- mRNA 3'-UTR binding