DZIP3 Gene Summary [Human]
Enables several functions, including phosphatase binding activity; polyubiquitin modification-dependent protein binding activity; and ubiquitin-protein transferase activity. Involved in protein polyubiquitination. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DZIP3 |
| Official Name | DAZ interacting zinc finger protein 3 [Source:HGNC Symbol;Acc:HGNC:30938] |
| Ensembl ID | ENSG00000198919 |
| Bio databases IDs | |
| Aliases | DAZ interacting zinc finger protein 3, human RNA-binding ubiquitin ligase of 138 kDa, protein phosphatase 1, regulatory subunit 66 |
| Synonyms | 2310047C04RIK, 2A-HUB, 6430549P11Rik, A230104G20, DAZ interacting protein 3, zinc finger, DAZ interacting zinc finger protein 3, hRUL138, KIAA0675, PPP1R66, RGD1563278, UURF2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DZIP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil domain
- enzyme
- E3 ubiquitin-protein ligase TTC3/DZIP3 domain
- Ring finger domain
- protein binding
- RING-like zinc finger
- RNA binding
- DZIP3/ hRUL138-like HEPN
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- tail domain
- phosphatase binding
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DZIP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- ubiquitin-protein ligase activity
- protein binding
- RNA binding
- metal ion binding
- polyubiquitin binding