LTBR Gene Summary [Human]
This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]
Details
| Type | Processed Transcript |
| Official Symbol | LTBR |
| Official Name | lymphotoxin beta receptor [Source:HGNC Symbol;Acc:HGNC:6718] |
| Ensembl ID | ENSG00000111321 |
| Bio databases IDs | |
| Aliases | lymphotoxin beta receptor, TNFR superfamily, member 3 |
| Synonyms | D12S370, Ltar, LT-BETA-R, LT-β-R, lymphotoxin beta receptor, lymphotoxin B receptor, Lymphotoxin Receptor, lymphotoxin-β receptor, Tnfbr, TNFCR, TNFR2-RP, TNFR3, TNF-R-III, TNFR-RP, TNFRSF3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LTBR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- traf2 binding domain
- ubiquitin protein ligase binding
- cytoplasmic domain
- TNFR/NGFR cysteine-rich region
- protein binding
- identical protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- transmembrane receptor
Pathways
Biological processes and signaling networks where the LTBR gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- cancer
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- diabetes mellitus
- organismal death
- inflammatory disorder
- laryngeal tumor
- head and neck neoplasia
role in cell
- cell death
- expression in
- apoptosis
- proliferation
- activation in
- phosphorylation in
- growth
- differentiation
- activity
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- cell borders
- perinuclear region
- cellular membrane
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LTBR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to mechanical stimulus
- immune response
- signal transduction
- positive regulation of JNK cascade
- myeloid dendritic cell differentiation
- apoptotic process
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of extrinsic apoptotic signaling pathway
- hemopoietic or lymphoid organ development
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- ubiquitin protein ligase binding