CR2
CR2 Gene Summary
This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | CR2 |
| Official Name | complement C3d receptor 2 [Source:HGNC Symbol;Acc:HGNC:2336] |
| Ensembl ID | ENSG00000117322 |
| Bio databases IDs | |
| Aliases | complement C3d receptor 2, Epstein-Barr virus receptor |
| Synonyms | C3DR,CD21,CD21/35,CD35,complement C3d receptor 2,complement receptor 2,CR,CVID7,EBV receptor,SLEB9 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- complement receptor
- signaling receptor activity
- iC3b/C3d-binding domain
- ectodomain
- protein binding
- receptor binding
- DNA binding
- CCP
- cytoplasmic domain
- protein homodimerization
- Sushi repeat (SCR repeat)
- transmembrane receptor
- SUSHI repeat
Pathways
Biological processes and signaling networks where the CR2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CR1
- CD19
- NFKB1
- interferon alpha
- RELA
- N-CoR
- C3
- CD81
- FCER2
- CD37
disease
- rheumatoid arthritis
- diabetic nephropathy
- systemic lupus erythematosus
- epithelial cancer
- common variable immunodeficiency type 7
- susceptibility to systemic lupus erythematosus
- dextran sodium sulfate-induced colitis
- nodal marginal zone lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
regulated by
- methotrexate
- CR2
- Ebna2
- Ebna-LP
- N-acetyl-L-cysteine
- OP9 cells
- IL4
- 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate
- P2RX7
- lipopolysaccharide
regulates
- Ca2+
- lipid
- CFLAR
- reactive oxygen species
- ERK
- IL6
- IL1B
- DDIT3
- CASP8
- p38 MAPK
role in cell
- number
- expression in
- proliferation
- recruitment
- accumulation in
- binding
- activation in
- production in
- apoptosis
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- plasma membrane extracellular face
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CR2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- viral entry into host cell
- negative regulation of complement activation, classical pathway
- complement activation, alternative pathway
- T cell mediated immunity
- immune response
- B cell differentiation
- complement activation, classical pathway
- B cell proliferation
- complement receptor mediated signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- membrane
- receptor complex
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- complement receptor activity
- DNA binding
- transmembrane signaling receptor activity
- protein homodimerization activity
- protein binding
- complement binding
- viral receptor activity
- immunoglobulin receptor binding