TCHP Gene Summary [Human]
Involved in apoptotic process; negative regulation of cell growth; and negative regulation of cilium assembly. Located in several cellular components, including apical cortex; cytoskeleton; and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | TCHP |
| Official Name | trichoplein keratin filament binding [Source:HGNC Symbol;Acc:HGNC:28135] |
| Ensembl ID | ENSG00000139437 |
| Bio databases IDs | |
| Aliases | trichoplein keratin filament binding, mitostatin |
| Synonyms | A930031F18RIK, AV279199, RGD1310813, TpMs, TRICHOPLEIN, trichoplein keratin filament binding, trichoplein, keratin filament binding |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TCHP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trichohyalin-plectin-homology domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- coronary artery disease
- myocardial infarction
- metabolic syndrome X
role in cell
- accumulation in
- production in
- growth
- apoptosis
- differentiation
- formation
- degradation in
- formation in
- size
- mitophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centriolar satellite
- ciliary transition fiber
- cilia
- cell periphery
- apical compartment
- cell cortex
- Plasma Membrane
- basal bodies
- centrosome
- Mitochondria
- desmosomes
- cell-cell contacts
- cytosol
- nuclear envelope
- apical cortex
- keratin intermediate filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TCHP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell growth
- apoptotic process
- cell projection organization
Cellular Component
Where in the cell the gene product is active
- centrosome
- keratin filament
- cytoplasm
- mitochondrion
- cytosol
- apical cortex
- desmosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding