ART4 Gene Summary [Human]
This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ART4 |
| Official Name | ADP-ribosyltransferase 4 (inactive) (Dombrock blood group) [Source:HGNC Symbol;Acc:HGNC:726] |
| Ensembl ID | ENSG00000111339 |
| Bio databases IDs | |
| Aliases | ADP-ribosyltransferase 4 (inactive) (Dombrock blood group), NAD(+)--protein-arginine ADP-ribosyltransferase 4 |
| Synonyms | 4432404K01Rik, ADP-ribosyltransferase 4, ADP-ribosyltransferase 4 (inactive) (Dombrock blood group), ARTC4, ATR4, CD297, DO, DO/ART4, DOK1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ART4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- VIP2
- NAD(P)-arginine ADP-ribosyltransferase
- enzyme
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell surface
- Extracellular Space
- cellular membrane
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ART4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- arginine metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- nucleotidyltransferase activity
- NAD+ ADP-ribosyltransferase activity