TENT2 Gene Summary [Human]
Enables 5'-3' RNA polymerase activity and polynucleotide adenylyltransferase activity. Involved in RNA metabolic process and negative regulation of RNA catabolic process. Predicted to be located in nucleus. Predicted to be part of nuclear RNA-directed RNA polymerase complex. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | TENT2 |
| Official Name | terminal nucleotidyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:26776] |
| Ensembl ID | ENSG00000164329 |
| Bio databases IDs | |
| Aliases | terminal nucleotidyltransferase 2, TUTase2 |
| Synonyms | 8030446C20Rik, APD4, GLD-2, PAPD4, terminal nucleotidyltransferase 2, TUT2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TENT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cid1 family poly A polymerase
- Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
- nucleotidyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- postsynaptic region
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TENT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of miRNA catabolic process
- histone mRNA catabolic process
- mRNA 3'-end processing
- hemopoietic progenitor cell differentiation
Cellular Component
Where in the cell the gene product is active
- nuclear RNA-directed RNA polymerase complex
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding