CDH15 Gene Summary [Human]
This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CDH15 |
| Official Name | cadherin 15 [Source:HGNC Symbol;Acc:HGNC:1754] |
| Ensembl ID | ENSG00000129910 |
| Bio databases IDs | |
| Aliases | cadherin 15 |
| Synonyms | cadherin 15, CDH14, CDH3, CDHM, MCAD, M-cadherin, MRD3, Muscle-cadherin precursor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDH15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cadherin, Y-type LIR-motif
- Cadherin repeat-like domain
- protein binding
Pathways
Biological processes and signaling networks where the CDH15 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Nucleus
- Golgi Apparatus
- cell-cell contacts
- caveolae
- neuromuscular junctions
- neurites
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDH15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium-dependent cell-cell adhesion
- cell-cell junction assembly
- adherens junction organization
- multicellular organismal development
- cell-cell adhesion mediated by cadherin
- cell morphogenesis
- cell adhesion
- homophilic cell adhesion
- cell migration
Cellular Component
Where in the cell the gene product is active
- adherens junction
- caveola
- extracellular vesicular exosome
- neuromuscular junction
- Golgi apparatus
- catenin complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- cadherin binding
- beta-catenin binding