SMOC2 Gene Summary [Human]
This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | SMOC2 |
| Official Name | SPARC related modular calcium binding 2 [Source:HGNC Symbol;Acc:HGNC:20323] |
| Ensembl ID | ENSG00000112562 |
| Bio databases IDs | |
| Aliases | SPARC related modular calcium binding 2 |
| Synonyms | 1700056C05Rik, 5430426J21Rik, bA270C4A.1, bA37D8.1, dJ421D16.1, DTDP1, MST117, MSTP117, MSTP140, SMAP2, Smoc2l, SPARC related modular calcium binding 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SMOC2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EFh_SPARC_EC
- Thyroglobulin_1 repeat associated disordered domain
- TY
- EF-hand domain pair
- calcium ion binding
- EFh
- protein binding
- KAZAL_FS
- heparin binding
- glycosaminoglycan binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- kidney disease
- epithelial cancer
- epithelial neoplasia
- cancer
- metastasis
- abdominal cancer
- colorectal cancer
- bladder exstrophy
- vitiligo
- dentin dysplasia with extreme microdontia and misshapen teeth type I
role in cell
- expression in
- proliferation
- migration
- cell viability
- morphology
- angiogenesis
- motility
- chemotaxis by
- epithelial-mesenchymal transition in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell periphery
- extracellular matrix
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SMOC2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of vascular endothelial growth factor signaling pathway
- positive regulation of vascular wound healing
- extracellular matrix organization
- positive regulation of fibroblast growth factor receptor signaling pathway
- positive regulation of endothelial cell chemotaxis
- positive regulation of DNA biosynthetic process
- positive regulation of endothelial cell migration
- positive regulation of mitotic cell cycle
- positive regulation of angiogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- basement membrane
- cell periphery
Molecular Function
What the gene product does at the molecular level
- extracellular matrix binding
- protein binding
- calcium ion binding
- heparin binding