LGR5 Gene Summary [Human]
The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | LGR5 |
| Official Name | leucine rich repeat containing G protein-coupled receptor 5 [Source:HGNC Symbol;Acc:HGNC:4504] |
| Ensembl ID | ENSG00000139292 |
| Bio databases IDs | |
| Aliases | leucine rich repeat containing G protein-coupled receptor 5 |
| Synonyms | FEX, GPR49, GPR67, GRP49, HG38, leucine rich repeat containing G protein-coupled receptor 5, LOC687868 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LGR5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- protein phosphatase 1 regulatory subunit 42
- ectodomain
- Leucine rich repeat
- 7 transmembrane receptor (rhodopsin family)
- Leucine rich repeat N-terminal domain
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine Rich repeats (2 copies)
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the LGR5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- oral squamous cell carcinoma
- organismal death
- hypopharyngeal squamous cell carcinoma
- melanoma
- melanoma cancer
- oropharyngeal squamous-cell carcinoma
- colorectal cancer
- neoplastic cell transformation
- colon epithelial cancer
role in cell
- apoptosis
- expression in
- proliferation
- phosphorylation in
- binding in
- differentiation
- development
- signaling in
- tumorigenicity
- commitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- Golgi Apparatus
- trans Golgi network
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LGR5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inner ear development
- G-protein coupled receptor signaling pathway
- hair follicle development
- positive regulation of canonical Wnt receptor signaling pathway
- oocyte differentiation
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- activation of adenylate cyclase activity
- epithelial cell proliferation involved in renal tubule morphogenesis
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- plasma membrane
- trans-Golgi network membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- G-protein coupled peptide receptor activity
- transmembrane signaling receptor activity
- protein binding
- protein-hormone receptor activity