ITK Gene Summary [Human]
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ITK |
| Official Name | IL2 inducible T cell kinase [Source:HGNC Symbol;Acc:HGNC:6171] |
| Ensembl ID | ENSG00000113263 |
| Bio databases IDs | |
| Aliases | IL2 inducible T cell kinase |
| Synonyms | EMT, EMTTK, IL2-inducible T-cell kinase, LPFS1, LYK, PSCTK2, Tcsk, Tsk |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ITK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein kinase (unclassified specificity)
- Tec homology domain
- SH3 domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- non-membrane spanning protein tyrosine kinase
- protein binding
- Pleckstrin homology-like domain
- Src-homology 2 binding domain
- protein-tyrosine kinase
- Protein kinase domain
- proline rich domain
- Sh3 domain binding motif
- Src Homology 3 domain superfamily
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- BTK motif
- tyrosine kinase domain
- PH domain
- Src homology 2 (SH2) domain
- SH1 domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the ITK gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- cancer
- ovarian cancer
- papillary thyroid cancer
- extraskeletal osteosarcoma
- fibrosarcoma
- renal clear cell adenocarcinoma
- synovial sarcoma
- malignant granular cell tumor
- follicular thyroid carcinoma
role in cell
- response
- proliferation
- apoptosis
- binding in
- quantity
- expression in
- phosphorylation in
- differentiation
- binding
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble membrane fraction
- membrane/cytoplasmic fraction
- membrane fraction
- Nucleus
- Plasma Membrane
- intercellular junctions
- immunological synapses
- cytosol
- periplasmic membranes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ITK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular defense response
- gamma-delta T cell activation
- NK T cell differentiation
- signal transduction
- T cell activation
- adaptive immune response
- protein phosphorylation
- positive regulation of cytokine production
- T cell receptor signaling pathway
- intracellular signal transduction
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cell-cell junction
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- metal ion binding